Breakthrough Procedure Eliminates Insulin Need for Type 2 Diabetes Patients

A new study has shown that 86% of patients with type 2 diabetes who underwent a novel procedure no longer needed insulin after participating in a two-year trial. This breakthrough could potentially benefit millions of people worldwide who are living with the condition.

The study, led by Dr. Celine Busch from Amsterdam University Medical Center, was presented at the United European Gastroenterology Week congress in Vienna, Austria. It involved 14 participants aged between 28 and 75, who were observed for 24 months.

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Type 2 diabetes is a chronic condition where the body either becomes resistant to insulin or doesn’t produce enough of it, leading to elevated blood sugar levels. If left unmanaged, this can result in serious health complications such as heart disease, kidney failure, nerve damage, and even amputations.

While diet, exercise, and medications like insulin can help manage the condition, insulin therapy often comes with side effects, including weight gain, and can be costly depending on location.

In this study, Dr. Busch employed a procedure known as Recellularization via Electroporation Therapy (ReCET). This involves using electric pulses to create small, irreversible holes in cell membranes, enhancing the body’s sensitivity to its own insulin. Although the exact mechanism is not yet fully understood, the results were promising.

After undergoing the procedure, participants followed a strict two-week liquid diet and then began taking semaglutide, a medication used to manage type 2 diabetes. By the 6- and 12-month check-ins, 12 out of the 14 participants had stopped using insulin, and they continued to manage without it at the 24-month mark. No severe side effects were reported, though one participant experienced nausea.

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Dr. Busch emphasized that ReCET, combined with semaglutide, shows great potential as a safe and effective way to eliminate the need for insulin therapy. Unlike drug-based treatments that require daily adherence, ReCET offers a compliance-free solution that addresses the underlying cause of diabetes by improving insulin sensitivity.

Future trials with larger sample sizes will be conducted to confirm these results. Although the procedure holds promise, further research and time will be required before ReCET becomes widely available. This comes on the heels of other advances in diabetes care, including a once-weekly insulin shot and technology to detect diabetes through voice analysis and tongue appearance.

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